The Immunology Research Group is seeking a highly motivated, innovative and resourceful Scientist to
help advance our understanding on the immunological aspects of hemophilia and clotting factor
replacement therapies, as well as to advance our hematology pipeline. The successful candidate will
perform exploratory in vitro and in vivo experiments using state-of-the-art techniques and approaches.
She/he will develop cellular and molecular models and assays to investigate immune responses to and
mechanism of action of clotting factors.

Responsibilities:

• design, perform and analyze in vitro and in vivo experiments to assess the efficacy, mechanism of
action and immunogenicity of clotting factor replacement therapies in preclinical and clinical studies
• use cell lines and primary immune cells from in vivo and clinical samples to build cellular models
• develop and use techniques to monitor molecular mechanism
• deliver data to support preclinical project milestones and medical affairs publication goals
• share and present scientific results to group members and multi-disciplinary research teams, and at
external conferences
• contribute to publications and written reports
• contribute to a collaborative team culture, by developing relationships with other research and
clinical colleagues
• work well in a matrixed, fast-paced environment

Qualifications:

The ideal candidate
• is proficient in immune cell isolation (from lymphoid tissues and peripheral blood), cell line and
primary cell cultures, Western blot and immunoprecipitation, plate- and imaging-based assays,
microscopy, gene expression, sequencing
• is proficient in multi-color flow cytometry (sample preparation, data collection and analysis)
• has experience with assay development (e.g. establishing plate-based biochemical and/or cell-based
assays)
• has experience working on mouse models of human diseases (breeding, dosing, ex vivo studies)
• keeps updated on relevant literature and applies knowledge to thoughtful experimental design,
troubleshooting and interpretation of results
• communicates effectively and collaborates in a multidisciplinary team environment
• has experience in people management
• is comfortable with changing direction and taking risks

Requirements:

• Ph.D. in Immunology/Molecular or Cell Biology with 1-5 years of postdoctoral experience
• direct experience using in vivo and in vitro models to study biological systems
• independent scientific thinking, innovative problem solving
• proven track record of publishing and presenting work in notable scientific forums
• excellent oral and written communication skills

Contact: Kata Kis-Toth (katalin.kistoth@bioverativ.com)

Job Opportunity at Bioverativ

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