Research Associate/Senior Research Associate, Immuno-engineering


An opportunity to join RootPath’s precision immunotherapy team in Cambridge, MA. You will contribute to our pre-clinical efforts leveraging novel single cell sequencing techniques and personalizing cancer therapies. The ideal candidate is innovative and self-motivated with an exceptional desire to lead the way in next generation call therapies to cure cancer

About the Position

Successful candidates will join a small and nimble industry team reporting directly to the research lead scientist.  There will be opportunities to interact with all levels of the company and the ability to work as an initial member in building a global immunotherapy company. Applicants must enjoy working in a fast-paced, dynamic research environment and be self-motivated; detail-orientation; committed to providing exceptional services; possess excellent organizational skills and the ability to multitask; and be able to follow complex instructions. Some responsibilities include:

  • Develop and optimize microfluidic and biochemical assays for the manipulation of T cells, including: droplet PCR assays, high throughput cloning and phenotypic assays
  • Characterize T cell repertoires using immunological assays including flow cytometry
  • Build reporter cell lines for phenotypic readout of immunology assays
  • Maintain an electronic lab notebook
  • Contribute to the design of experiments and overall project direction
  • Aid in upkeep of lab including general lab supply stocking and maintenance
  • Present research data internally to other members of the team


  • BS/MS in biochemistry, cell biology, immunology or related discipline and 1+ years of relevant research experience
  • Experience with in vitro immunology studies and functional T cell assay development using techniques such as multi-color flow cytometry, ELISPOT, and cell based immune assays desired
  • Experience in gene delivery, especially T cells, using synthetic mRNA transfection or lentiviral vector transduction preferred
  • Experience in mammalian cell culture including primary human lymphocyte
  • Experience with standard molecular biology techniques, including but not limited to, qPCR, gel electrophoresis, molecular cloning, and RNA in vitro transcription preferred
  • Excellent computer skills including use of digital notebooks, graphing software, and some familiarity with programing
  • Scientifically rigorous, highly organized, and with significant attention to detail
  • Excellent oral and written communication skills
  • Ability to work in concert with a team as well as independently

RootPath is an emerging life science company focusing on precision immunotherapy based in Cambridge, MA. By combining advanced molecular engineering and computational design, we have developed a number of proprietary technologies in comprehensive profiling of single cells and the immune system.  These technologies promise to bring precision medicine to the immunotherapy of cancer and autoimmune diseases. Working together with our partners, we will leverage these leading technologies to characterize the immune system with unprecedented comprehensiveness, and provide valuable guidance for drug developers, physicians and patients alike. RootPath was founded in 2017 by Drs. Xi Chen, Le Cong, Yinqing Li and Ely Porter, with seed-stage financing led by Ventures.

Interested applicants should apply online at indeed or massbio.

Job Opportunity at RoothPath Genomics

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